development of innovative treatments for pancreatic cancer
Silexion Therapeutics is a pioneering developmental stage
company Formerly known as Silenseed, the company has
developed its first-generation LODERTM product
We strive to develop novel therapies that can revolutionize cancer treatment, providing patients with new hope and improved outcomes
Silexion Company Profile
Silexion Therapeutics is a pioneering developmental stage company dedicated to the development of innovative treatments for pancreatic cancer.
The company conducted phase 2 clinical trial with its first generation product which has shown positive efficacy results vs the control of chemotherapy alone.
Silexion’s commitment to pushing the boundaries of therapeutic advancements in the field of oncology, is focused in enhancing its first-generation product (LODERTM) to develop a new formulated product which will improve the clinical efficacy that Silexion observed with its first-generation product against pancreatic cancer.
Core Technologies
RNA Interference (RNAi)
Targeted Drug Delivery
Our vision is to establish treatment dedicated to addressing the complex and devastating impact of cancer on individuals and communities worldwide.
SIL-103- Silexion Product
Silexion Technology is a platform technology consisting of siRNA and PLG microparticle product for the treatment of solid tumors.
Why SIL 103?
- Improve siRNA delivery by formulating into bioabsorbable PLG microparticles of about 30-70 µm that will simultaneously release two siRNAs for 2-3 months in the pancreatic tumor.
- Add 2 siRNAs with a stronger inhibition profile towards G12V, and G12D, the most abundant mutants in Pancreatic Cancer.
- SIL 103 is delivered directly into the tumor and can be spread throughout the tumor surface area due to its liquid emulsion formulation.